Table 2.
Odds ratios and 95% confidence intervals for HCC by tertiles of circulating OPN and AFP levels in the EPIC nested case-control study.
| Tertiles | Continuously, | |||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | Ptrend | per increasea | 10% | |
| OPN | ||||||
| Tertile range, (ng/ml) | <49.1 | 49.1–58.6 | >58.6 | |||
| No of cases/controls | 14/65 | 24/65 | 62/64 | |||
| Matching factors onlyb | 1.00 | 3.09 [1.17–8.13] | 12.26 [4.40–34.10] | <0.0001 | 1.33 [1.19–1.49] | |
| Multivariablec | 1.00 | 3.87 [1.27–11.78] | 13.76 [4.21–44.98] | <0.0001 | 1.30 [1.14–1.48] | |
| AFP | ||||||
| Tertile range, (ng/ml) | <3.3 | 3.3–4.6 | >4.6 | |||
| No of cases/controls | 9/67 | 15/63 | 76/64 | |||
| Matching factors onlyb | 1.00 | 2.02 [0.78–5.28] | 12.48 [4.87–32.02] | <0.0001 | 1.18 [1.11–1.25] | |
| Multivariablec | 1.00 | 1.97 [0.72–5.41] | 9.97 [3.70–26.86] | <0.0001 | 1.17 [1.09–1.25] | |
a
OPN and AFP levels correspond to a 10% increment after log transformation.
b
Odds ratios and 95% confidence intervals estimated by conditional logistic regression conditioned on the matching factors.
c
Additionally adjusted for body mass index (kg/m2, continuous), smoking status (never, former, current, unknown), baseline alcohol intake (g/d, continuous), and lifetime alcohol intake pattern (never drinkers, former drinkers, drinkers only at recruitment, lifetime drinkers, unknown).