Table 2.
All Studies Using CNS-Derived Myelinating Cells That Met the Latter Inclusion Criteria.
| Cell type: | OPCs | NRPs | adult NSPCs | embryonic NSPCs |
embryonic GRPs |
ESCs | iPS-NSCs |
|---|---|---|---|---|---|---|---|
| Study: | Bambakidis et al., 2004 Sun et al., 2014 Cao et al., 2010 |
Setoguchi et al., 2004 |
Hawryluk et al., 2014 Hofstetter et al., 2005 Karimi-Abdolrezaee et al., 2010 Mothe et al., 2013 |
Hu et al., 2012 Lu et al., 2010 Yasuda et al., 2011 |
Cao et al., 2005 Hu et al., 2013 |
McDonald et al.,1999 | Salewski et al., 2015 |
|
Genetic / Drug Treatment: |
Shh TROY inhibition CNTF |
Noggin | minocycline+ cyclosporine, Neurogenin-2, ChABC, HAMC- rPDGF |
Olig2/MBP activated T cells, cyclosporin A, No treatment |
D15A, Schwann cell co- transplant |
No treatment |
No treatment |
Studies that met inclusion criteria were grouped into 7 broad categories of cell types used for transplantation. Relevant genetic or pharmacologic additions are identified within each study.
Abbreviations: ChABC=Chondroitinase ABC, CNTF=Ciliary Neurotrophic Factor, ESC=Embryonic Stem Cells, GRP=Glial Restricted Precursor Cells, HAMC-rPDGF=Hyaluronan And Methyl Cellulose covalently modified with recombinant rat Platelet-Derived Growth Factor-A, iPS-NSC=induced Pluripotent Stem derived-Neural Stem Cells, NPC=Neural Precursor Cells, NRP=Neural Restricted Precursor cells, NSPC=Neural Stem Progenitor Cells, OPC=Oligodendrocyte Precursor Cells, Shh=Sonic hedgehog.