Table 3.

All Studies Using Schwann Cells That Met the Initial Inclusion Criteria.

Injury	Cells	Additions	Reported Behavior	Myelin Sparing	Other Sparing	Reference
Rat T10 contusion	Neonatal rat SCs	Anti-GalC antibodies	BBB: -	IHC: +	Increased BDA+ axon regeneration	Azanchi et al, 2004
Rat T8 contusion	Adult rat OEGs or SCs	none	BBB: +			Barakat et al, 2005
Rat T10 contusion	Adult rat OEGs or SCs	none	BBB: + Ladder: -		Increased sparing/ growth of axons from the Reticular Formation and Raphe and Vestibular Nuclei	Barbour et al, 2013
Rat T9 1.5 mm displacement	SVZ neurosphere and neonatal SKPs or SKP-SCs	none	BBB: + Sensory threshold: -	IHC: +	Increased 5HT and TH fibers	Biernaskie et al, 2007
Rat T10 clip compression	Adult rat SCs	none	BBB: -	IHC: +		Chi et al, 2010
Rat T9 contusion	Neonatal rat SCs	Fetal spinal cord suspension, NGF or BDNF	BBB: +		Increased CST axon growth	Feng et al, 2005
Rat clip crush	Neonatal rat SCs	none	BBB: +			Firouzi et al, 2006
Rat T8 weight drop	Adult rat SCs	LV-D15A; rolipram	BBB: +	TEM: +	Increased 5HT fibers, Increased sparing/ growth of axons from the Reticular Formation and Raphe and Vestibular Nuclei	Flora et al, 2013
Rat T8 contusion	Adult rat SCs	PST	BBB: +		Increased 5HT and CST axon growth	Ghosh et al, 2012
Rat T8 weight drop	Adult rat SCs	AdV-D15A or LV-D15A	BBB: -	TEM: +	Increased 5HT, DbH, and CGRP fibers	Golden et al, 2007
Mouse T8 compression	GFP+ P5 mouse SCs	AP or L1/L1-Fc	BMS: +	IHC: +	Increased 5HT fibers	Lavdas et al, 2010
Rat T10 contusion	Adult rat OEGs or SCs	none	BBB: -	Ephys: -	Increased NF stain with OEGs	Li et al, 2012
Mouse T8 crush	GFP+ P5 mouse SCs	AP or STX	BMS: +	IHC: +	Increased 5HT fibers	Papastefanaki et al, 2007
Rat T8 contusion	Adult rat SCs	Rolipram or cAMP	BBB: +	IHC: + TEM: +		Pearse et al, 2004a
Rat T9 contusion	Adult rat OEGs or SCs	MP/IL-10	BBB: + Foot rotation: + Foot fall errors: +		Increased 5HT fibers, Increased graft volume, Less cavitation	Pearse et al, 2004b
Rat T9 contusion	Adult rat OEGs and SCs	none	BBB: + Foot rotation: +	IHC: +	Increased 5HT, CST, and CGRP fibers	Pearse et al, 2007
Rat T8 contusion	Adult rat SCs	Rolipram or cAMP	BBB: - Kinematics: -	IHC: + WMS: +	No change in lesion volume	Sharp et al, 2012
Rat C4/5 crush	Neonatal GFP+ rat fibroblasts, neonatal SCs, or SKP-SCs	none	Cylinder: + Catwalk: +	IHC: + Ephys: +	Increased spared axons	Sparling et al, 2015
Rat T9 contusion	Adult rat OEGs and SCs	none	BBB: +	TEM: +	Increased propriospinal, supraspinal, and corticospinal axons	Takami et al, 2002
Rat C6 contusion	GFP+ adult rat SCs	bpV	Forelimb: + Sensorimotor: +		Decreased lesion, Increased penumbral neurons and vascularization	Walker et al, 2015
Rat T9 contusion	Adult rat GFP- SCs	none	BBB: - Foot rotation: +	IHC: +	Increased blood vessels in graft	Wang and Xu, 2014

Columns with a “+” indicate positive evidence within the performed experiment reported. Columns with a “-” indicate no evidence found within the performed experiment reported. Blank columns indicate no respective experiment reported. Highlighted rows indicate studies that passed the latter exclusion criteria.

Abbreviations: 5HT=5-hydroxytryptamine, AP=Alkaline Phosphatase, BBB=Basso, Beattie, Bresnahan locomotor rating scale, BDA=Biotinylated Dextran Amines, BDNF=Brain-Derived Neurotrophic Factor, bpV=bisperoxovanadium, CGRP=Calcitonin Gene-Related Peptide, CST=Corticospinal Tract, DbH=Dopamine beta Hydroxylase , Ephys=Electrophysiology, GFP=Green Fluorescence Protein, MP=Methylprednisolone, NF=Neurofilament, NGF=Nerve Growth Factor, OEG=Olfactory Ensheathing Glia , TEM=Transmission Electron Microscopy, IHC=Immunohistochemistry, PST=Polysialyltransferase, SC=Schwann Cells, SKD=Skin Derived precursor cells, STX=Sialyl-transferase X, SVZ=Sub-Ventricular Zone, T=thoracic level of spinal cord injury, TH=Tyrosine Hydroxylase, WMS=White Matter Sparing.