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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Neurobiol Dis. 2016 Jul 28;95:204–209. doi: 10.1016/j.nbd.2016.07.025

Figure 5. N159D prevents the accumulation of pathogenic conformations.

Figure 5

Detection of pathogenic PrP conformations using the 15B3 antibody. MoPrP-WT is immunoprecipitated by 15B3 in both young (day 1) and old flies (day 30), with the older flies accumulating higher amounts of PrPSc-like conformers. However, very small amounts of MoPrP-N159D are immunoprecipitated by 15B3. Controls on the left show the specificity of the antibody for MoPrP. * indicates a non-specific band.