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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: J Immunol. 2016 Aug 8;197(6):2509–2521. doi: 10.4049/jimmunol.1502659

Figure 7. anti-OX40 immunotherapy maintains Nur77GFP induction on tumor antigen-specific T cells.

Figure 7

OVA tolerant POET mice were inoculated on the hind flank with either MCA205 WT or MCA205 OVA tumors and treated according to the experimental design in A). The first cohort of animals was analyzed at B) day 6 (top row) after adoptive transfer and the second (bottom row) at day 13 after adoptive transfer. Expression of Nur77GFP is indicated on live/TCRβ+/CD8+/Thy1.1+ T cells from the tumor. An independent cohort of animals were treated according to A) and monitored for long-term survival. C) spider plots and D) survival curves are shown for these animals. Data are representative of 3 independent experiments with a minimum of n=5 animals per tumor model and treatment group.