Figure 5.

Anxiety-like behavior was evaluated the next day after the last cycle of RSD in the open field test. (A) Mice subjected to RSD and treated with vehicle, had significantly less number of center entries than HCC and RSD mice treated with imipramine. (B) Mice treated with vehicle and subjected to RSD took more time to enter the center of the open field, and this was reversed with imipramine treatment. (C) A decreased time spent in the open field was assessed in RSD mice treated with vehicle and this was prevented with imipramine treatment. Bars represent the mean±SEM. Means with asterisk (*) are significantly different from each other (p<0.05). Control=HCC; RSD=Repeated Social Defeat; #= number; (s)=seconds