. Author manuscript; available in PMC: 2017 Sep 15.

Published in final edited form as: J Immunol. 2016 Aug 12;197(6):2119–2130. doi: 10.4049/jimmunol.1600133

Table I.

NaI supplementation of the water for 2–4 wk is sufficient for maximal development of severe TEC H/P

		TEC H/P Severity Score ^b
NaI (wk)^a	Plain (wk)^a	0	1+	2+	3+	4+	5+
2	6	6	0	2	0	6	6
3–4	4	1	0	0	1	5	11
3–4	15	1	0	0	0	2	8
4 ^c	0	2	2	0	1	0	0
8	0	0	1	0	0	2	8

Groups of IFN-γ^−/−CD28^−/− NOD.H-2h4 mice, 6 wk of age, were given NaI in their water for the indicated time. Mice in lines 1–3 were then maintained on plain water (no NaI) as indicated before thyroids were removed.

Numbers of mice with the indicated TEC H/P severity scores.

Thyroids were removed after 4 wk on NaI water, indicating that disease is not fully developed when mice in lines 1–3 were removed from NaI supplementation.