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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: J Immunol. 2016 Aug 15;197(6):2382–2389. doi: 10.4049/jimmunol.1600994

Figure 5. Charon protein delivers Rel68 to PARP-1-regulated promoters.

Figure 5

A. Charon interacts with Relish-Kenny-Imd5 complex in perinuclear bodies and shuttles between them and PARP-1-bearing promoters. B. Upon IMD pathways activation Relish protein cleaved into C-terminal domain, which remains bound with inhibitor-complex and Rel68 N-terminal domain which remains bound with Charon but looses interaction with Kenny/Imd5. Under control of Charon NLS Rel68 is transported to chromatin and by mediation of Charon localized into PARP-1 occupied promoter. Binding of Relish in promoters triggers transcription on innate immune genes.