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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: J Immunol. 2016 Aug 12;197(6):2079–2089. doi: 10.4049/jimmunol.1501805

Figure 1. ADAP is not required for initial expansion, but is required for optimal survival to memory after LM-OVA challenge.

Figure 1

Naïve WT (CD45.1/2) and ADAP−/− (CD45.2) OT-I T cells were cotransferred into CD45.1 hosts and challenged with LM-OVA. Splenocytes (A–B) or lymphocytes from the liver (C–D) were isolated and stained for cell surface markers. (A and C) Number of WT (black circles) or ADAP−/− (open squares) OT-I T cells after LM-OVA challenge. (B and D) The frequency of ADAP−/− OT-I T cells at each time point is expressed as a percentage of WT OT-I T cells. The results are compiled from 12 independent experiments, with at least 4 mice per time point (± SEM). *, p < 0.05; **, p < 0.01; ***, p < 0.001.