Table 3.

Regression analyses for prediction of clinical outcomes by pain modulatory genes and psychological factors

Dependent Variable	Genetic and Psychological Predictors	Demographics Only		Add Baseline Variable		Add Genotype		Add Psychological Factor		Add Interaction		P- Value of Full Model	R2 of Full Model
		R2	P- value	R2	P- value	R2 Increment	P- value	R2 Increment	P- value	R2 Increment	P- value
Pre-Operative Status
Average Pain Intensity	KCNS1(rs734784) + TSK-11	0.246	<.0001			0.000	0.957	0.039	0.007	0.055	0.004	<.0001	0.341
Worst Pain Intensity	KCNS1(rs734784) + TSK-11	0.163	<.0001			0.009	0.480	0.081	0.000	0.071	0.001	<.0001	0.324
12 Month Post-Operative Course (AUC)
Average Pain Intensity	ADRB2(rs1042713) + PHQ	0.188	<.0001	0.160	<.0001	0.001	0.863	0.044	0.002	0.048	0.0036	<.0001	0.442
	AVPR1A(rs1042615) + TSK-11	0.188	<.0001	0.160	<.0001	0.010	0.338	0.005	0.304	0.036	0.0197	<.0001	0.399
Quick-DASH Average	ADRB2(rs1042713)+ PHQ	0.102	0.004	0.110	<.0001	0.018	0.193	0.028	0.024	0.091	0.0001	<.0001	0.349
Quick-DASH Peak	ADRB2(rs1042713) + PHQ	0.136	0.001	0.021	0.077	0.029	0.109	0.002	0.543	0.058	0.0106	<.0001	0.246
12 Month Post-Operative Status
Average Pain Intensity	GCH1(rs3783641) + STAI	0.097	0.020	0.039	0.026	0.032	0.122	0.012	0.199	0.086	0.0025	0.000	0.267

Table 3 Key: *Bolded variables met our criterion for strong statistical evidence for an interaction (p < 0.0027 for addition of interaction term); AUC = area under curve; DASH = Disability of Arm, Shoulder, and Hand questionnaire; FPQ = Fear of Pain Questionnaire; PCS = Pain Catastrophizing Scale; PHQ = Patient Health Questionnaire; STAI = State Trait Anxiety Inventory; TSK-11 = Tampa Scale of Kinesiophobia