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. 2016 Aug 18;99(3):728–734. doi: 10.1016/j.ajhg.2016.06.028

Figure 1.

Figure 1

HNRNPH2 Domains and Conservation among Various Family Members and across Species

(A) HNRNPH2 domains. The numbers above (100, 200, 300, and 400) represent the amino acid sequence. Dotted arrows indicate the location of de novo variants at amino acid positions 206 and 209. Abbreviations are as follows: NLS, nuclear localization sequence; RRM, RNA recognition motifs; G, glycine-rich domain; Y, tyrosine-rich domain; R, arginine-rich domain.

(B) Highly conserved sequences among members of the HNRNPH family, including HNRNPs H1 (H), H2 (H’), and F proteins. Highlighted boxes indicate amino acid residues 206 and 209 reported.

(C) Cross species conservation of amino acids 206 and 209. Highlighted boxes indicate amino acid residues 206 and 209 reported.