Figure 6.

Overexpression of PLS3 and CORO1C but Not of TMOD3 Improve Endocytosis in SMN-Deficient Cells

(A and B) Quantification of the R1-gated population shows that PLS3 and CORO1C significantly increase endocytosis in SMN-deficient HEK293T cells after 20 min treatment.

(C) Immunoblots show siRNA-mediated knockdown of SMN and overexpression of PLS3, CORO1C, and TMOD3 in HEK293T cells (n = 5, 10⁴ cells measured per FACS experiment). n.s., non-significant; ^∗p < 0.05; ^∗∗∗p < 0.001, two-tailed Student’s t test.

Error bars represent SEM.