FIGURE 3.

Demography of cystic fibrosis in a sample of 78,627 patients in different countries or demographic regions – (A) Prevalence by gender: average of 52% male and 48% female. (B) Within the sample group, 86% have been genotyped and approximately 38% are ΔF508-homozygous, 35% ΔF508-heterozygous and 13% bearing other CFTR (cystic fibrosis transmembrane conductance regulator) mutants in both alleles. (C) About 50% of patients are under 18 years and 50% are 18 years or older. Data compiled from the latest registry reports of Europe (EU; European Cystic Fibrosis Society [ECFS], 2016), United States (US; Cystic Fibrosis Foundation [CFF], 2015), Canada (CA; Cystic Fibrosis Canada [CFC], 2016), Australia (AU; Cystic Fibrosis Federation Australia [CFFA], 2016) and Brazil (BR; Brazilian Cystic Fibrosis Study Group [GBEFC], 2016).