. 2016 Aug 4;9:35–42. doi: 10.1016/j.dib.2016.08.004

Table 4.

Comparison between the calculated P-gp modulatory activity values (pFAR) and observed values of 11 flavonoids which exhibited a significant experimental P-gp inhibitory activity expressed by Inhibitory efficiency.

Compound	Inhibitory efficiency (observed activity)^a	Classification (by observed activity)	Calculated pFAR (Predicted activity)	Classification (by predicted activity)
Naringenin	56.93	Active inhibitor	−0.39	Active inhibitor^b
Quercetin	72.73	Active inhibitor	−0.04	Active inhibitor^b
Morin	56.63	Active inhibitor	−0.07	Active inhibitor^c
Silymarin	60	Active inhibitor	0.42	Inducer^c
Epigallocatechin gallate (EGCG)	168.18	Strong inhibitor	−1.03	Strong inhibitor^d
Epicatechin gallate (ECG)	95.45	Active inhibitor	−0.61	Active inhibitor^d
Biochenin A	198.04	Strong inhibitor	−1.30	Strong inhibitor^b
Hesperidin	164.41	Strong inhibitor	−1.32	Strong inhibitor^e
Demethylnobiletin	87.43	Active inhibitor	−1.13	Strong inhibitor^e
5HHMF	65.47	Active inhibitor	0.44	Inducer^e
Nobiletin	45.71	Active inhibitor	1.58	Inducer^e
Positive control (verapamil)	100	Strong inhibitor	–	–

Inhibitory efficiency calculated as percentage compared to a positive control; verapamil.

From Chung et al. [10].

From Zhang and Morris [12].

From Kitagawa et al. [11].

From El-Readi et al. [13].