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. 2016 Aug 30;9:15–17. doi: 10.1016/j.eucr.2016.07.012

Table 1.

Diagnostic criteria for serotonin syndrome1

Sternbach's criteria Hunter's criteria
  • 1.

    Patient on serotonergic agent

  • 2.

    Absence of other causes or etiologies

  • 3.

    No current use of neuroleptic agent

  • 4.
    Presence of three of the following:
    • •
      Mental status change (confusion, hypomania, restlessness, ataxia)
    • •
      Agitation
    • •
      Myoclonus
    • •
      Hyperreflexia
    • •
      Diaphoresis
    • •
      Shivering
    • •
      Tremor
    • •
      Diarrhea
    • •
      Incoordination
    • •
      Fever
  • 1.

    Patient on serotonergic agent

  • 2.
    Presence of any of the following:
    • •
      Spontaneous clonus
    • •
      Inducible clonus AND agitation OR diaphoresis
    • •
      Ocular clonus AND agitation OR diaphoresis
    • •
      Tremor AND hyperreflexia
    • •
      Hypertonic AND hyperthermia (>38 °C) AND ocular clonus OR inducible clonus