Table 2.
Autograft immune effector cells and survival after autologous hematopoietic stem cell transplantation.
| Study [reference] |
Disease (number of patients) |
Autograft immune effector cells | 2-year overall survival rates | 2-year progression-free survival rates |
|---|---|---|---|---|
| Dean et al., 2005 [24] | Diffuse large B-cell lymphoma (53) |
DC 1 ≥ 0.06 0.45 × 109 cells/kg |
55% | |
| DC 1 < 0.06 0.45 × 109 cells/kg |
35% | |||
| (P < 0.04) | ||||
|
| ||||
| Schmidmaier et al., 2008 [25] | Multiple myeloma (41) |
CD4 ≥ 0.45 × 109
cells/kg |
80% | |
| CD4 < 0.45 × 109
cells/kg |
40% | |||
| (P < 0.003) | ||||
|
| ||||
| Porrata et al., 2014 [26] | Diffuse large B-cell lymphoma (379) |
Lymphocyte to monocyte ratio ≥ 1.0 | 85% | 75% |
| Lymphocyte to monocyte ratio < 1.0 | 40% | 30% | ||
| (P < 0.0001) | (P < 0.0001) | |||
|
| ||||
| Porrata et al., 2014 [27] | Hodgkin's lymphoma (183) |
Lymphocyte to monocyte ratio ≥ 1.0 | 95% | 85% |
| Lymphocyte to monocyte ratio < 1.0 | 60% | 30% | ||
| (P < 0.0001) | (P < 0.0001) | |||
|
| ||||
| Porrata et al., 2015 [28] | T-cell non-Hodgkin's lymphoma (109) |
Lymphocyte to monocyte ratio ≥ 1.0 | 90% | 80% |
| Lymphocyte to monocyte ratio < 1.0 | 45% | 30% | ||
| (P < 0.0001) | (P < 0.0001) | |||
|
| ||||
| Porrata et al., 2016 [29] | Non-Hodgkin's lymphoma (122) |
NK ≥ 0.06 0.45 × 109 cells/kg |
85% | 79% |
| NK < 0.06 0.45 × 109 cells/kg |
70% | 45% | ||
| (P = 0.06) | (P < 0.02) | |||
DC: dendritic cells; NK: natural killer cells.