Table 2.
Clinical characteristics of hematologic patients that were reported to have Leuconostoc infection in the literature.
| Case | Age/sex | Underlying disease | Condition | CVC (removal) | Identified bacteria from blood culture | Prior therapy | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|
| 1 | 31/M | Acute myeloid leukemia | Pneumonia (postallogeneic BMT) | yes (yes) | Leuconostoc sp. | VCM | CAZ, CPFX | Died |
| 2 | 18/F | Hodgkin's lymphoma | Septic shock, GVHD (postallogeneic BMT) | yes (yes) | Leuconostoc mesenteroides | VCM, IPM/CS → CPFX | DPT | Improved |
| 3 | 35/M | Acute myeloid leukemia | Line-related bacteremia (postallogeneic BMT) | yes (yes) | Leuconostoc mesenteroides | VCM, CFPM, penicillin | DPT | Improved |
| 4 | 25/F | Non-Hodgkin's lymphoma | Febrile neutropenia (after chemotherapy) | N/A | Leuconostoc pseudomesenteroides Enterococcus faecium | N/A | AMPC/CVA, GM, CPFX, ABPC | Improved |
| 5 | 34/F | Acute myeloid leukemia | Febrile neutropenia, GVHD (postallogeneic PBSCT) | yes (N/A) | Leuconostoc sp. | TEIC | ABPC, GM | Improved |
| 6 | 52/F | Acute myeloid leukemia | Right thigh cellulitis (after chemotherapy) | yes (N/A) |
Leuconostoc sp. Stenotrophomonas maltophilia |
VCM | IPM/CS, GM → ST, CLDM | Improved |
| 7 | 73/M | Non-Hodgkin's lymphoma | Febrile neutropenia (after chemotherapy) | N/A | Leuconostoc sp. | PAPM/BP, GM | PAPM/BP, GM, VCM | Died |
| 8 | 52/F | Acute myeloid leukemia (granulocytic sarcoma) |
Febrile neutropenia (after chemotherapy) | yes (N/A) | Leuconostoc lactis | MEPM → CPFX, TEIC | LZD → TGC | Improved |
| 9 | 64/M | Non-Hodgkin's lymphoma | Meningitis (after chemotherapy) | N/A | Leuconostoc sp. | CTRX → ABPC + GM | MEPM | Improved |
BMT: bone marrow transplantation, GVHD: graft-versus-host disease, PBSCT: peripheral blood stem cell transplantation, CVC: central venous catheter, N/A: not applicable, sp.: species, VCM: vancomycin, IPM/CS: imipenem/cilastatin, CPFX: ciprofloxacin, CFPM: cefepime, TEIC: teicoplanin, PAPM/BM: panipenem/betamipron, GM: gentamycin, MEPM: meropenem, CTRX: ceftriaxone, ABPC: ampicillin, CAZ: ceftazidime, DPT: daptomycin, AMPC/CVA: amoxicillin/clavulanate, ST: sulfamethoxazole/trimethoprim, CLDM: clindamycin, LZD: linezolid, and TGC: tigecycline.