Table 2.
Summary of notable histopathology findings.
| Organs | Observations∗ | Incidence of observations per group Dose groups (mg/kd bw/d) |
Incidence of observations per group Dose groups (mg/kd bw/d) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | 180 | 300 | 375 | Control | 180 | 300 | 375 | ||||
| Survivors | Died early | Survivors | Died early | ||||||||
| Males | Females | ||||||||||
| Epididymides | Decreased amount of spermatozoa | 0/10 | 0/10 | 1/10 | 1/9 | 1/1 | / | / | / | / | / |
| Lack of spermatozoa | 0/10 | 0/10 | 2/10 | 8/9 | 0/1 | / | / | / | / | / | |
| Testes | Decreased intensity of spermatogenesis | 0/10 | 0/10 | 5/10 | 9/9 | 1/1 | / | / | / | / | / |
| Liver | Congestion | 0/10 | / | / | 0/9 | 1/1 | 0/10 | / | / | 2/2 | 0/10 |
| Centrilobular necrosis | 0/10 | / | / | 0/9 | 1/1 | 0/10 | / | / | 2/2 | 0/10 | |
| Lungs | Alveolar emphysema | 2/10 | / | / | 1/9 | 1/1 | 2/10 | / | / | 2/2 | 2/10 |
| Hyperplasia of BALT | 2/10 | / | / | 1/9 | 0/1 | 1/10 | / | / | 0/2 | 0/10 | |
| Congestion | 0/10 | / | / | 0/9 | 1/1 | 0/10 | / | / | 2/2 | 0/10 | |
| Prostate | Decreased amount of secretion | 0/10 | / | / | 3/9 | 0/1 | / | / | / | / | / |
| Skin | Exudative dermatitis | 0/10 | 1/1 | 1/1 | 2/9 | 0/1 | 0/10 | 0/10 | 0/10 | 0/10 | 0/10 |
| Uterus | Dilatation | / | / | / | / | / | 1/10 | / | / | 0/2 | 4/9 |
∗Number of animals with observations/number of animals examined.
/, not examined; BALT, bronchus associated lymphoid tissue; mg/kg bw/d, milligrams per kilogram body weight per day.