Table 7.

Summary of statistically significant hematological findings.

	Dose group (mg/kg bw/d)
	Males					Females
	Control   n = 10	180  n = 10	300  n = 10	375  n = 9	Historical range	Control  n = 10	180  n = 10	300   n = 8	375  n = 10	Historical range
WBC (×109/L)	7.91 ± 0.97	7.69 ± 1.49	6.69 ± 1.79	8.13 ± 1.65	4.60–13.86	6.20 ± 1.81	5.63 ± 1.02	∗4.74 ± 0.98	6.57 ± 1.66	2.96–12.94
MONO (%)	2.82 ± 0.48	∗3.70 ± 0.85	2.62 ± 1.17	2.67 ± 0.68	0.6–4.1	2.09 ± 0.64	2.26 ± 0.31	2.51 ± 0.45	1.81 ± 0.48	0.4–3.1
EOS (%)	1.41 ± 0.40	∗1.04 ± 0.34	∗∗0.78 ± 0.20	∗∗0.69 ± 0.31	0.4–3.3	1.06 ± 0.43	0.78 ± 0.34	0.76 ± 0.32	∗∗0.52 ± 0.20	0.5–2.0
RBC (×1012/L)	9.51 ± 0.40	∗∗8.43 ± 0.48	∗∗8.31 ± 0.64	∗∗8.34 ± 0.33	6.20–10.26	8.67 ± 0.28	∗∗7.92 ± 0.40	∗∗8.01 ± 0.52	∗8.19 ± 0.67	7.61–9.31
HGB (g/L)	168.70 ± 5.93	162.00 ± 7.47	161.90 ± 10.84	163.67 ± 3.50	109–184	161.20 ± 3.77	∗154.60 ± 6.82	158.88 ± 9.49	165.20 ± 6.99	145–169
MCV (fL)	48.04 ± 1.40	∗∗52.96 ± 2.96	∗∗53.94 ± 2.15	∗∗54.17 ± 2.68	45.0–53.7	51.13 ± 2.09	∗∗54.18 ± 2.71	∗∗54.78 ± 2.15	∗∗55.14 ± 1.65	47.0–55.0
MCH (pg)	17.75 ± 0.41	∗∗19.24 ± 0.81	∗∗19.51 ± 0.57	∗∗19.66 ± 0.86	16.7–19.4	18.61 ± 0.62	∗19.54 ± 0.89	∗∗19.85 ± 0.56	∗∗20.25 ± 1.29	17.3–19.7
MCHC (g/L)	369.70 ± 4.40	∗363.70 ± 9.07	∗361.80 ± 5.92	∗362.89 ± 4.26	339–376	363.90 ± 5.90	360.60 ± 3.53	362.75 ± 5.50	367.20 ± 17.07	351–368
RET (%)	3.15 ± 0.30	∗∗3.67 ± 0.32	∗∗4.18 ± 1.72	∗∗3.94 ± 0.56	2.51–4.65	3.93 ± 0.49	4.14 ± 0.79	3.91 ± 0.63	4.36 ± 1.22	3.17–6.16

Values are expressed as mean ± standard deviation. Historical Range based on data from 40 male and 38 female Hsd.Brl.Han Wistar control rats aged 19-20 weeks.

mg/kg bw/d, milligrams per kilogram body weight per day; L, liter; fL, femtoliters; pg, picograms; n, number of animals; ^∗ p < 0.05 and ^∗∗ p < 0.01.