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. 2016 Sep 5;4:89. doi: 10.3389/fcell.2016.00089

Figure 1.

Figure 1

Adjunctive and diagnostic assays of FISH in clinical cytogenetics. (A) The detection of di-centric, tri-centric, and tetra-centric ring chromosome 18 using a centromeric probe D18Z2 for chromosome 18. Left panel shows normal chromosome 18, dicentric ring 18 in top, and tetracentric ring 18 in bottom, right panel shows dicentric ring 18 and tricentric/tetracentric ring 18 in insets by FISH. (B) The detection of a derivative chromosome 16 from a 2q32/16p13.3 translocation by whole chromosome painting probes for chromosomes 2 (WCP2) and 16 (WCP16). (C) The detection of ABL1/BCR gene fusions in interphase and metaphase cells by dual color double fusion probes (thin arrows point to the normal signal and thick arrows point to the abnormal fusion signals). (D) Diagnostic use of ETV6 and RUNX1 probes for the detection of two fusion signals for a cryptic t(12;21)(p13;q22), loss of an ETV6 signal and gain of three extra RUNX1 signals (thin arrows point to the fusion signals and thick arrows to extra RUNX1 signals). All images are from Yale clinical cytogenetics laboratory.