Table 1. The Sequences of Designed Control shRNA and shRNA Targeting Human PKM2 Gene.

	Intensive therapy
Control shRNA	5'-CCGGGAGGCTTCTTATAAGTGTTTACTCGAGTAAACACTTATAAGAAGCCTCTTTTTG-3'
PKM2 shRNA-946	5'-CCGGGCTGTGGCTCTAGACACTAAACTCGAGTTTAGTGTCTAGA-GCCACAGCTTTTTG-3'
PKM2 shRNA-1408	5'-CCGGCTACCACTTGCAATTATTTGACTCGAGTCAAATAATTGCAAG-TGGTAGTTTTTG-3'
PKM2 shRNA-1411	5'-CCGGCCACTTGCAATTATTTGAGGACTCGAGTCCTCAAATAATTGCAAGTGGTTTTTG-3'

PKM2, the M2 isoform of pyruvate kinase.

The underlines indicate the target sequences for PKM2, and the bold letters show the loop sequences.