Table 1. Summary of the 63 Membrane Proteins Identified on TMT-Labeling Proteomic Analysis.
| No. | IPI No. | Protein | AD Treg log2 | Normal Treg log2 | Fit_ratio (AD Treg/normal Treg) |
|---|---|---|---|---|---|
| 1 | IPI00225390.5 | Tax=10090 GS=Cox6b1 Cytochrome c oxidase subunit 6B1 | 13.2891 | 13.6851 | −0.5458 |
| 2 | IPI00626994.3 | Tax=10090 GS=Ipo5 Isoform 1 of Importin-5 | 8.6202 | 8.9498 | −0.4795 |
| 3 | IPI00116877.5 | Tax=10090 GS=Tnpo2 transportin-2 | 10.0495 | 10.2952 | −0.3955 |
| 4 | IPI00798527.1 | Tax=10090 GS=Tnpo1 Isoform 2 of Transportin-1 | 8.9195 | 9.1111 | −0.3415 |
| 5 | IPI00109727.1 | Tax=10090 GS=Thy1 Thy-1 membrane glycoprotein | 12.6675 | 12.7869 | −0.2693 |
| 6 | IPI00165694.1 | Tax=10090 GS=Tomm34 Isoform 1 of Mitochondrial import receptor subunit TOM34 | 10.8784 | 10.9784 | −0.2498 |
| 7 | IPI00230540.1 | Tax=10090 GS=Vdac1 Isoform Mt-VDAC1 of Voltage-dependent anion-selective channel protein 1 | 11.784 | 11.8828 | −0.2487 |
| 8 | IPI00938467.1 | Tax=10090 GS=Lck proto-oncogene tyrosine-protein kinase LCK isoform a | 11.7831 | 11.8807 | −0.2475 |
| 9 | IPI00229935.3 | Tax=10090 GS=Ptprb Receptor-type tyrosine-protein phosphatase beta | 11.5368 | 11.5056 | −0.1187 |
| 10 | IPI00120466.1 | Tax=10090 GS=Cd5 T-cell surface glycoprotein CD5 | 8.0688 | 7.973 | −0.0541 |
| 11 | IPI00121309.2 | Tax=10090 GS=Ndufs3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | 8.9542 | 8.8549 | −0.0505 |
| 12 | IPI00130344.3 | Tax=10090 GS=Clic1 Chloride intracellular channel protein 1 | 11.6859 | 11.5823 | −0.0463 |
| 13 | IPI00125929.2 | Tax=10090 GS=Ndufa4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 | 13.1399 | 13.0186 | −0.0286 |
| 14 | IPI00118986.1 | Tax=10090 GS=Atp5o;LOC100047429 ATP synthase subunit O, mitochondrial | 11.6007 | 11.4692 | −0.0184 |
| 15 | IPI00311682.5 | Tax=10090 GS=Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 | 11.5598 | 11.4171 | −0.0072 |
| 16 | IPI00930882.1 | Tax=10090 GS=Slc3a2 4F2 cell-surface antigen heavy chain isoform a | 9.1199 | 8.973 | −0.0029 |
| 17 | IPI00119138.1 | Tax=10090 GS=Uqcrc2 Cytochrome b-c1 complex subunit 2, mitochondrial | 10.6442 | 10.4834 | 0.011 |
| 18 | IPI00323881.2 | Tax=10090 GS=Kpnb1 Importin subunit beta-1 | 11.0277 | 10.8536 | 0.0243 |
| 19 | IPI00845575.2 | Tax=10090 GS=Atl3 atlastin-3 isoform 1 | 9.676 | 9.4848 | 0.0413 |
| 20 | IPI00404182.2 | Tax=10090 GS=Rhob Rho-related GTP-binding protein RhoB | 11.4687 | 11.2678 | 0.0511 |
| 21 | IPI00133240.1 | Tax=10090 GS=Uqcrfs1 Cytochrome b-c1 complex subunit Rieske, mitochondrial | 9.7465 | 9.5288 | 0.0679 |
| 22 | IPI00129792.1 | Tax=10090 GS=Kpna4 Importin subunit alpha-4 | 11.9586 | 11.7313 | 0.0775 |
| 23 | IPI00111885.2 | Tax=10090 GS=Uqcrc1 Cytochrome b-c1 complex subunit 1, mitochondrial | 11.6341 | 11.4064 | 0.0778 |
| 24 | IPI00133706.1 | Tax=10090 GS=Rab1b Ras-related protein Rab-1B | 12.626 | 12.3771 | 0.0991 |
| 25 | IPI00121288.5 | Tax=10090 GS=Ndufb10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | 13.8617 | 13.6027 | 0.1091 |
| 26 | IPI00467062.2 | Tax=10090 GS=Tapbp Isoform Long of Tapasin | 11.0743 | 10.8151 | 0.1093 |
| 27 | IPI00116770.1 | Tax=10090 GS=Rab18 Ras-related protein Rab-18 | 9.8218 | 9.5597 | 0.1122 |
| 28 | IPI00130280.1 | Tax=10090 GS=Atp5a1 ATP synthase subunit alpha, mitochondrial | 13.2884 | 13.015 | 0.1235 |
| 29 | IPI00122548.4 | Tax=10090 GS=Vdac3 Voltage-dependent anion-selective channel protein 3 | 10.805 | 10.5292 | 0.126 |
| 30 | IPI00622837.1 | Tax=10090 GS=Gm6265 cytochrome c oxidase subunit 6C-like | 13.0492 | 0012.7682 | 0.1311 |
| 31 | IPI00989100.1 | Tax=10090 GS=Rab1 22 kDa protein | 12.8755 | 12.5816 | 0.144 |
| 32 | IPI00411115.1 | Tax=10090 GS=Rab8b Ras-related protein Rab-8B | 10.2913 | 9.9681 | 0.1733 |
| 33 | IPI00990016.1 | Tax=10090 GS=Rab14 protein variant | 9.3363 | 8.9936 | 0.1928 |
| 34 | IPI00127983.1 | Tax=10090 GS=Tmed2;Gm10698 Transmembrane emp24 domain-containing protein 2 | 9.7858 | 9.4415 | 0.1944 |
| 35 | IPI00119618.1 | Tax=10090 GS=Canx Calnexin | 14.1173 | 13.7627 | 0.2048 |
| 36 | IPI00987138.1 | Tax=10090 GS=LOC100047577 cytochrome b5 type B-like | 14.909 | 14.5461 | 0.213 |
| 37 | IPI00224518.2 | Tax=10090 GS=Rab5c Ras-related protein Rab-5C | 10.0028 | 9.6327 | 0.2203 |
| 38 | IPI00407954.2 | Tax=10090 GS=Rap1b Ras-related protein Rap-1b | 13.2249 | 12.8544 | 0.2207 |
| 39 | IPI00759999.1 | Tax=10090 GS=Prdx5 Isoform Cytoplasmic+peroxisomal of Peroxiredoxin-5, mitochondrial | 10.2007 | 9.812 | 0.2389 |
| 40 | IPI00110849.1 | Tax=10090 GS=H2-Aa H-2 class II histocompatibility antigen, A-K alpha chain | 8.9564 | 8.5546 | 0.2519 |
| 41 | IPI00131176.1 | Tax=10090 GS=mt-Co2 Cytochrome c oxidase subunit 2 | 15.1602 | 14.7242 | 0.2861 |
| 42 | IPI00408892.2 | Tax=10090 GS=Rab7 Ras-related protein Rab-7a | 9.3238 | 8.8811 | 0.2928 |
| 43 | IPI00555000.2 | Tax=10090 GS=Uqcrb Cytochrome b-c1 complex subunit 7 | 13.7627 | 13.3125 | 0.3003 |
| 44 | IPI00341282.2 | Tax=10090 GS=Atp5f1 ATP synthase subunit b, mitochondrial | 14.4398 | 13.9238 | 0.3661 |
| 45 | IPI00403079.4 | Tax=10090 GS=Cd47 Isoform 1 of Leukocyte surface antigen CD47 | 14.8106 | 14.2506 | 0.4102 |
| 46 | IPI00128856.2 | Tax=10090 GS=Ptprc Isoform 3 of Receptor-type tyrosine-protein phosphatase C | 12.3368 | 11.7648 | 0.4221 |
| 47 | IPI00114377.1 | Tax=10090 GS=Cox7a2 Cytochrome c oxidase subunit 7A2, mitochondrial | 15.4368 | 14.8582 | 0.4287 |
| 48 | IPI00466570.4 | Tax=10090 GS=Tmed10 Isoform 1 of Transmembrane emp24 domain-containing protein 10 | 14.3041 | 13.6975 | 0.4567 |
| 49 | IPI00230241.6 | Tax=10090 GS=Atp5e ATP synthase subunit epsilon, mitochondrial | 11.4311 | 10.8022 | 0.4791 |
| 50 | IPI00117978.1 | Tax=10090 GS=Cox4i1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 13.5709 | 12.9405 | 0.4805 |
| 51 | IPI00985828.1 | Tax=10090 GS=LOC100045864 h-2 class I histocompatibility antigen, D-P alpha chain-like isoform 4 | 13.513 | 12.847 | 0.5161 |
| 52 | IPI00316976.3 | Tax=10090 GS=Ptprcap Protein tyrosine phosphatase receptor type C-associated protein | 11.7475 | 11.0731 | 0.5245 |
| 53 | IPI00850057.1 | Tax=10090 GS=LOC100044874 h-2 class I histocompatibility antigen, K-W28 alpha chain-like isoform 1 | 13.431 | 12.7493 | 0.5319 |
| 54 | IPI00108844.1 | Tax=10090 GS=M6pr Cation-dependent mannose-6-phosphate receptor | 12.1324 | 11.4145 | 0.568 |
| 55 | IPI00953773.1 | Tax=10090 GS=Ssr4 translocon-associated protein subunit delta isoform 1 precursor | 12.3014 | 11.5799 | 0.5716 |
| 56 | IPI00857192.1 | Tax=10090 GS=Fis1 mitochondrial fission 1 protein isoform 2 | 12.1282 | 11.4031 | 0.5752 |
| 57 | IPI00120719.4 | Tax=10090 GS=Cox5a Cytochrome c oxidase subunit 5A, mitochondrial | 14.0156 | 13.2366 | 0.6292 |
| 58 | IPI00674006.3 | Tax=10090 GS=Tmem173 Isoform 1 of Transmembrane protein 173 | 10.2513 | 9.444 | 0.6575 |
| 59 | IPI00323897.3 | Tax=10090 GS=Rab11a Ras-related protein Rab-11A | 10.9208 | 10.048 | 0.723 |
| 60 | IPI00759904.1 | Tax=10090 GS=Cyb5r3 Isoform 2 of NADH-cytochrome b5 reductase 3 | 12.5679 | 11.641 | 0.7771 |
| 61 | IPI00128450.1 | Tax=10090 GS=Esyt1 Isoform 1 of Extended synaptotagmin-1 | 10.771 | 9.8392 | 0.782 |
| 62 | IPI00120346.3 | Tax=10090 GS=Rab27b Ras-related protein Rab-27B | 10.8696 | 9.876 | 0.8437 |
| 63 | IPI00172243.1 | Tax=10090 GS=H2-Ab1 H-2 class II histocompatibility antigen, A-K beta chain | 11.5565 | 9.9744 | 1.4322 |
TMT, Tandem Mass Tags; Treg, regulatory T; AD, atopic dermatitis.