Table 2. Summary of the 16 Plasma Membrane Proteins Identified on TMT-Labeling Proteomic Analysis.
| No. | IPI No. | Protein | AD Treg log2 | Normal Treg log2 | Fit_ratio (AD Treg/normal Treg) |
|---|---|---|---|---|---|
| 1 | IPI00109727.1 | Tax=10090 GS=Thy1 Thy-1 membrane glycoprotein | 12.6675 | 12.7869 | −0.2693 |
| 2 | IPI00938467.1 | Tax=10090 GS=Lck proto-oncogene tyrosine-protein kinase LCK isoform a | 11.7831 | 11.8807 | −0.2475 |
| 3 | IPI00229935.3 | Tax=10090 GS=Ptprb Receptor-type tyrosine-protein phosphatase beta | 11.5368 | 11.5056 | −0.1187 |
| 4 | IPI00120466.1 | Tax=10090 GS=Cd5 T-cell surface glycoprotein CD5 | 8.0688 | 7.973 | −0.0541 |
| 5 | IPI00130344.3 | Tax=10090 GS=Clic1 Chloride intracellular channel protein 1 | 11.6859 | 11.5823 | −0.0463 |
| 6 | IPI00311682.5 | Tax=10090 GS=Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 | 11.5598 | 11.4171 | −0.0072 |
| 7 | IPI00930882.1 | Tax=10090 GS=Slc3a2 4F2 cell-surface antigen heavy chain isoform a | 9.1199 | 8.973 | −0.0029 |
| 8 | IPI00404182.2 | Tax=10090 GS=Rhob Rho-related GTP-binding protein RhoB | 11.4687 | 11.2678 | 0.0511 |
| 9 | IPI00127983.1 | Tax=10090 GS=Tmed2;Gm10698 Transmembrane emp24 domain-containing protein 2 | 9.7858 | 9.4415 | 0.1944 |
| 10 | IPI00110849.1 | Tax=10090 GS=H2-Aa H-2 class II histocompatibility antigen, A-K alpha chain | 8.9564 | 8.5546 | 0.2519 |
| 11* | IPI00403079.4 | Tax=10090 GS=Cd47 Isoform 1 of Leukocyte surface antigen CD47 | 14.8106 | 14.2506 | 0.4102 |
| 12* | IPI00128856.2 | Tax=10090 GS=Ptprc Isoform 3 of Receptor-type tyrosine-protein phosphatase C | 12.3368 | 11.7648 | 0.4221 |
| 13* | IPI00985828.1 | Tax=10090 GS=LOC100045864 h-2 class I histocompatibility antigen, D-P alpha chain-like isoform 4 | 13.513 | 12.847 | 0.5161 |
| 14* | IPI00316976.3 | Tax=10090 GS=Ptprcap Protein tyrosine phosphatase receptor type C-associated protein | 11.7475 | 11.0731 | 0.5245 |
| 15* | IPI00850057.1 | Tax=10090 GS=LOC100044874 h-2 class I histocompatibility antigen, K-W28 alpha chain-like isoform 1 | 13.431 | 12.7493 | 0.5319 |
| 16* | IPI00172243.1 | Tax=10090 GS=H2-Ab1 H-2 class II histocompatibility antigen, A-K beta chain | 11.5565 | 9.9744 | 1.4322 |
TMT, Tandem Mass Tags; Treg, regulatory T; AD, atopic dermatitis.
*Six plasma membrane proteins upregulated specifically in AD Treg cells.