Table 2.

Predictors of proper inhalation achieving: results of univariate and multivariate linear regressions on patients characteristics and tested devices

Attempts before achieving the first proper inhalation (N)	Univariate analysis		Multivariate analysis
	delta (95 % C.I.)	p	delta (95 % C.I.)	p
Age a	0.08 (0.05─0.10)	< 0.0001	0.07 (0.05─0.09)	< 0.0001
Sex (female)	−0.03 (-0.18─0.12)	NS
Disease (COPD vs asthma)	0.36 (0.21─0.51)	< 0.0001
Previous experience with DPI	0.14 (-0.02─0.30)	NS
Previous instructed to DPI	0.12 (-0.04─0.28)	NS
Device (Breezhaler vs Genuair)	1.01 (0.84─1.18)	< 0.0001	1.00 (0.84─1.16)	< 0.0001
Device (Handihaler vs Genuair)	0.91 (0.73─1.10)	< 0.0001	0.87 (0.69─1.05)	< 0.0001
Successful rate at the first attempt (%)	Univariate analysis		Multivariate analysis
	OR (95 % C.I.)	p	OR (95 % C.I.)	p
Age a	0.85 (0.81─0.89)	< 0.0001	0.84 (0.80─0.88)	< 0.0001
Sex (female)	0.96 (0.71─1.3)	NS
Disease (COPD vs asthma)	0.43 (0.31─0.58)	<0.0001
Previous experience with DPI	0.59 (0.43─0.81)	< 0.001	0.64 (0.45─0.92)	< 0.05
Previous instructed to DPI	0.64 (0.47─0.88)	< 0.01
Device (Breezhaler vs Genuair)	0.17 (0.12─0.25)	< 0.0001	0.15 (0.10─0.22)	< 0.0001
Device (Handihaler vs Genuair)	0.19 (0.12─0.29)	< 0.0001	0.17 (0.11─0.27)	< 0.0001
Total time required for the first proper inhalationb (min)	Univariate analysis		Multivariate analysis
	delta (95 % C.I.)	p	delta (95 % C.I.)	p
Age a	0.24 (0.14─0.33)	< 0.0001	0.25 (0.18─0.32)	< 0.0001
Sex (female)	−0.29 (-0.99─0.40)	NS
Disease (COPD vs asthma)	1.12 (0.42─1.81)	<0.005
Previous experience with DPI	0.26 (-0.47─0.99)	NS
Previous instructed to DPI	0.17 (-0.55─0.88)	NS
Device (Breezhaler vs Genuair)	7.76 (7.15─8.37)	< 0.0001	7.74 (7.15─8.33)	< 0.0001
Device (Handihaler vs Genuair)	2.45 (1.78─3.12)	< 0.0001	2.30 (1.65─2.95)	< 0.0001

DPI dry powder inhaler, NS not significant

^aEvery 5-years increment

^bincluding patient time and nurse demonstration