Skip to main content
. 2016 Sep 2;12:1744806916666284. doi: 10.1177/1744806916666284

Figure 2.

Figure 2.

GM3S depletion fully reverses neuropathic pain, even in diabetic mice. GM3S KO HFD mice were divided into diabetic (Group 1; 2 h GTT glucose levels ≥182 mg/dL) or non-diabetic (Group 2, <182 mg/dL) based on a threshold of ≥ 2 SD above the mean for 2 h glucose levels in our WT RD mice (n = 80). As shown in (a), the fasting baseline levels of glucose in the two GM3S KO HFD groups remained higher than WT RD baseline levels, but the 2 h glucose levels in Group 2 were not higher than those of WT RD mice (WT RD, n = 9; WT HFD, n = 9; GM3S KO RD, n = 9; GM3S KO HFD overall, n = 23; GM3S KO HFD Group 1, n = 6; GM3S KO HFD Group 2, n = 17). (b) The Von Frey Pain Behavior Test demonstrated that the withdrawal threshold required to elicit a response in GM3S KO HFD Groups 1 and 2 was significantly higher than WT HFD, but similar to WT RD and GM3S KO RD mice. Values are expressed as mean ± SE. *p < 0.05, **p < 0.01, ***p < 0.001.