Table 4.
Statistical significance of differences in cardiovascular mortality evaluated by the Kaplan-Meier analysis for vitamin D signaling pathway genes and CASR in hemodialysis patients undergoing the 7-year prospective study.
| Tested polymorphism | N | Major homozygotes versus heterozygotes versus minor homozygotesa | Dominant model of inheritanceb | Recessive model of inheritanceb | Additive model of inheritanceb |
|---|---|---|---|---|---|
| GC rs7041 | 458 | GG versus GT versus TT P = 0.329 |
TT + GT versus GG P = 0.475 |
TT versus GT + GG P = 0.648 |
TT versus GG P = 0.513 |
| GC rs1155563 | 472 | TT versus CT versus CC P = 0.316 |
CC + CT versus TT P = 0.542 |
CC versus CT + TT P = 0.992 |
CC versus TT P = 0.846 |
| GC rs2298849 | 472 | TT versus CT versus CC P = 0.906 |
CC + CT versus TT P = 0.797 |
CC versus CT + TT P = 0.921 |
CC versus TT P = 0.956 |
| RXRA rs10881578 | 472 | AA versus AG versus GG P = 0.778 |
GG + AG versus AA P = 0.617 |
GG versus AG + AA P = 0.391 |
GG versus AA P = 0.516 |
| RXRA rs10776909 | 472 | CC versus CT versus TT P = 0.294 |
TT + CT versus CC P = 0.176 |
TT versus CT + CC P = 0.595 |
TT versus CC P = 0.647 |
| RXRA rs749759 | 464 | GG versus AG versus AA P = 0.705 |
AA + AG versus GG P = 0.899 |
AA versus AG + GG P = 0.416 |
AA versus GG P = 0.429 |
| VDR rs1544410 | 461 | GG versus AG versus AA P = 0.760 |
AA + AG versus GG P = 0.098 |
AA versus AG + GG P = 0.976 |
AA versus GG P = 0.286 |
| VDR rs2228570 | 449 | CC versus CT versus TT P = 0.217 |
TT + CT versus CC P = 0.067 |
TT versus CT + CC P = 0.206 |
TT versus CC P = 0.043 |
| CASR rs7652589 | 435 | GG versus AG versus AA P = 0.119 |
AA + AG versus GG P = 0.781 |
AA versus AG + GG P = 0.090 |
AA versus GG P = 0.168 |
CASR: calcium-sensing receptor gene, GC: group-specific component gene, RXRA: retinoic X receptor alpha gene, and VDR: vitamin D receptor gene.
aMultiple-sample test P.
bLog rank test P.