FIG. 4.

Top network of differentially expressed genes acutely (within 6 h) after sports-related concussion (SRC). Functional analysis of the top selected genes identified by microarray within 6 h of SRC centered on the “Inflammatory Response, Infectious Disease, Renal and Urological Disease” network. The network is graphically represented as nodes (genes) and lines (the biological relationship between genes). Red and green shaded nodes represent up- and down-regulated genes, respectively; empty nodes are those that are biologically linked to differentially expressed genes based on the evidence in the literature, but not differentially expressed in the analyzed samples. Solid lines represent a direct interaction between the two gene products while dotted lines indicates indirect interactions. Network hubs and their connections to each other are noted in bold. Only those genes with direct or indirect connections to one of the hubs were displayed in this figure for simplicity. Color image is available online at www.liebertpub.com/neu