Table 3.

Patient and Caregiver Quality-of-Life-Relevant Outcomes

	No. of studies
	Addressed outcome	Majority results significant	Percentage of studies
Patient QOL-relevant domains
Patient outcomes described	96		77
Pain	37	9	24
Dyspnea	14	3	21
Depressive symptoms	33	12	36
Anxiety	22	9	41
Other symptomsa	40	15	38
Existential or spiritual concerns	11	4	36
Communication or care planning	18	12	67
Experience or satisfaction	20	8	40
Functional status	37	12	32
HRQOL	38	10	26

	Total No. of studies	Majority results significant	Percentage of studies
Majority of results significant in majority of QOL-relevant domains	96	42	44
No. of domains addressed
1	24	15	63
2	12	10	83
3–10	60	17	28
Majority of total number of results significant in total number of QOL-relevant outcomes	96	34	35
No. of outcomes addressed
1	11	9	82
2–4	27	11	41
5–13	58	14	24

	Addressed outcome	Majority results significant	Percentage of studies
Caregiver QOL-relevant domains
Caregiver outcomes described	52		42
Depressive symptoms	21	12	57
Anxiety	6	2	33
Other symptomsa	8	5	63
Existential or spiritual concerns	3	0	0
Communication or care planning	4	3	75
Experience or satisfaction	8	5	63
HRQOL	7	3	43

	Total No. of studies	Majority results significant	Percentage of studies
Majority of results significant in majority of QOL-relevant domains	52	31	60
No. of domains addressed
1	26	18	69
2	14	6	43
3–5	12	7	58
Majority of total number of results significant in total number of QOL-relevant outcomes	52	30	58
No. of outcomes addressed
1	18	13	72
2–3	13	6	46
4–10	21	11	52

^aOther symptoms include all symptoms other than pain, dyspnea, depressive symptoms, and anxiety (e.g., fatigue, anorexia, nausea, and diarrhea).

HRQOL, health-related quality of life; QOL, quality of life.