Table 2.
Trephined (Improvement) and Perfusion CT
| Pre-surgery | p value | Post-surgery | p value | Pre-surgery | p value | Post-surgery | p value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TTP in sec | TTP Defect | TTP Healthy | ||||||||||
| trephined | Yes | No | Yes | No | Yes | No | Yes | No | ||||
| ACA | 20.813 | 19.991 | N.S | 21.651 | 19.177 | N.S | 21.074 | 19.673 | N.S | 19.714 | 19.296 | N.S |
| MCA | 22.976 | 20.776 | N.S | 20.606 | 18.726 | N.S | 19.222 | 19.648 | N.S | 19.245 | 18.706 | N.S |
| PCA | 22.407 | 20.443 | N.S | 21.103 | 19.123 | N.S | 20.707 | 20.214 | N.S | 20.065 | 19.505 | N.S |
| BG | 21.535 | 18.945 | N.S | 19.681 | 18.205 | N.S | 19.054 | 18.982 | N.S | 19.315 | 18.164 | N.S |
| Mean | 21.911 | 20.031 | N.S | 20.471 | 18.808 | N.S | 20.033 | 19.629 | N.S | 19.585 | 18.918 | N.S |
| MTT in sec | MTT Defect | MTT Healthy | ||||||||||
| trephined | Yes | No | Yes | No | Yes | No | Yes | No | ||||
| ACA | 8.743 | 9.221 | N.S | 9.457 | 8.498 | N.S | 5.694 | 7.988 | 0.059 | 6.704 | 6.294 | N.S |
| MCA | 7.998 | 8.424 | N.S | 6.310 | 6.420 | N.S | 5.059 | 7.776 | 0.031 | 5.058 | 5.740 | N.S |
| PCA | 6.912 | 8.188 | N.S | 7.312 | 6.519 | N.S | 6.096 | 7.061 | N.S | 5.959 | 6.683 | N.S |
| BG | 6.855 | 7.916 | N.S | 7.250 | 6.268 | N.S | 4.886 | 8.478 | 0.01 | 5.781 | 6.204 | N.S |
| Mean | 7.536 | 8.436 | N.S | 7.450 | 6.926 | N.S | 5.434 | 7.825 | 0.039 | 5.875 | 6.230 | N.S |
| CBV in mL/100 g | CBV Defect | CBV Healthy | ||||||||||
| trephined | Yes | No | Yes | No | Yes | No | Yes | No | ||||
| ACA | 5.988 | 6.926 | N.S | 7.288 | 5.971 | N.S | 6.986 | 6.992 | N.S | 8.225 | 6.600 | N.S |
| MCA | 10.046 | 10.764 | N.S | 11.620 | 9.834 | N.S | 11.964 | 9.671 | N.S | 14.707 | 8.519 | 0.002 |
| PCA | 10.010 | 8.151 | N.S | 11.900 | 10.354 | N.S | 11.837 | 9.712 | N.S | 13.946 | 12.913 | N.S |
| BG | 8.185 | 7.094 | N.S | 8.668 | 7.499 | N.S | 7.696 | 6.312 | N.S | 8.988 | 6.403 | 0.057 |
| Mean | 8.432 | 8.235 | N.S | 9.808 | 8.414 | N.S | 9.620 | 8.172 | N.S | 11.466 | 8.609 | N.S |
| CBF in mL/100 g/min | CBF Defect | CBF Healthy | ||||||||||
| trephined | Yes | No | Yes | No | Yes | No | Yes | No | ||||
| ACA | 65.338 | 75.699 | N.S | 108.542 | 78.357 | N.S | 111.579 | 104.395 | N.S | 145.251 | 100.888 | N.S |
| MCA | 120.055 | 118.841 | N.S | 136.565 | 136.851 | N.S | 181.115 | 126.344 | 0.031 | 193.855 | 147.953 | N.S |
| PCA | 128.095 | 94.604 | N.S | 162.046 | 112.766 | N.S | 159.674 | 116.778 | N.S | 208.467 | 130.653 | N.S |
| BG | 126.385 | 96.091 | N.S | 109.307 | 107.077 | N.S | 140.907 | 97.787 | 0.024 | 146.257 | 110.958 | N.S |
| Mean | 109.288 | 96.303 | N.S | 128.401 | 108.763 | N.S | 148.318 | 111.326 | 0.04 | 173.474 | 122.612 | 0.049 |
An unpaired t-test was applied and grouped based on either the presence or absence of improvement (trephined yes or no); p values are reported if they were less than 0.08 (trend) or if they were less than 0.05 (statistically significant). The remainder of the values is presented as not significant. There were no differences between trephined and not trephined on the defective side either pre- or post-surgery. On the healthy side, we observed a statistically shorter MTT in patients who showed improvement, as well as higher pre-surgical CBF values and higher postsurgical CBV values compared to patients who were not trephined.
CT, computed tomography; TTP, time to peak; ACA, anterior cerebral artery; N.S., not significant; MCA, middle cerebral artery; PCA, posterior cerebral artery; BG, basal ganglia; MTT, mean transient time; CBV, cerebral blood volume; CBF, cerebral blood flow.