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Flow patterns regulate subendothelial matrix remodeling from a native basement membrane (collagen IV, laminin) to a fibronectin-rich provisional matrix. While fibronectin deposition is inhibited by laminar flow, disturbed flow promotes fibronectin deposition, potentially through effects on endothelial integrin activation, transforming growth factor-β (TGFβ) signaling, and fibronectin expression.
