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. 2016 Sep 6;6:32400. doi: 10.1038/srep32400

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effect of Sanhe Decoction (SHD) on myocardial ischemia pathological changes (A) and biochemical changes of SOD, CK, cAMP and cTnI serum levels (B) in left anterior descending coronary artery (LAD) occlusion rats. LAD occlusion rats were intragastricly treated with SHD-low 1.88 g/(kg.day), SHD-middle 3.75 g/(kg.day), SHD-high 7.5 g/(kg.day) and isosorbide mononitrate (IMT, 4 mg/kg) for one week. The myocardial pathological changes were analyzed by optical microscope analysis on the eighth day. The muscular fibers (A) (magnification, × 30,000) of myocardial ultrastructure images were taken. Values represent means ± SEM, n = 8. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. model.