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. 2016 Sep 6;6:32400. doi: 10.1038/srep32400

Table 1. The shared genes of CVDs and GIDs.

GeneSymbol Gene name Types of CVDs Types of GIDs
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 Heart Defects, Congenital Gastroesophageal Reflux
ACE angiotensin I converting enzyme Heart Failure, Cardiovascular Diseases Stomach Neoplasms
ADRB1 adrenoceptor beta 1 Heart Failure, Cardiovascular Diseases Stomach Neoplasms
ADRB2 adrenoceptor beta 2, surface Heart Failure Stomach Neoplasms
AHR aryl hydrocarbon receptor Heart Defects, Congenital; Heart diseases Stomach Neoplasms
ALB albumin Heart Diseases; Heart Failure; Cardiovascular Diseases Stomach Neoplasms
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 Heart Diseases Stomach Neoplasms
AVP arginine vasopressin Heart Failure Gastrointestinal Hemorrhage
CAT catalase Heart Failure Stomach Ulcer
CSF2 colony stimulating factor 2 (granulocyte-macrophage) Heart Failure Gastrointestinal Hemorrhage
CSF3 colony stimulating factor 3 (granulocyte) Heart Failure; Heart Diseases Gastrointestinal Diseases
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 Cardiovascular Diseases Gastroesophageal Reflux
EDN1 endothelin 1 Heart Failure; Cardiovascular Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular disease, unspecified; Ischemic heart disease Gastrointestinal Diseases
F2R coagulation factor II (thrombin) receptor Cardiovascular Disorders Stomach Neoplasms
GCG glucagon Heart Failure; Heart Diseases Stomach Diseases
GDF15 growth differentiation factor 15 Heart Failure; Cardiovascular disease, unspecified Gastrointestinal Neoplasms
GHRL ghrelin/obestatin prepropeptide Heart Failure Stomach Ulcer
GHSR   Cardiovascular disease, unspecified Gastrointestinal Diseases and Disorders, miscellaneous
HMOX1 heme oxygenase (decycling) 1 Heart Failure; Cardiovascular disease, unspecified Stomach Neoplasms; Gastroparesis
HSPB1 heat shock 27 kDa protein 1 Heart Failure Stomach Neoplasms
IL1B interleukin 1, beta Heart Failure; Heart Valve Diseases Stomach Ulcer; Stomach Neoplasms; Gastritis, Atrophic
IL6 interleukin 6 Heart Failure Stomach Neoplasms
MT2A metallothionein 2A Heart Diseases Stomach Neoplasms
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) Cardiovascular Diseases; Heart Defects, Congenital Stomach Neoplasms;
NOS2 nitric oxide synthase 2, inducible Heart Failure, Cardiovascular Abnormalities Stomach Ulcer
NOS3 nitric oxide synthase 3 (endothelial cell) Cardiovascular Diseases; Heart Failure Stomach Ulcer, Stomach Neoplasms
NRG1 neuregulin 1 Heart Failure Stomach Ulcer
PLAU plasminogen activator, urokinase Heart Rupture, Post-Infarction Stomach Neoplasms
POMC proopiomelanocortin Heart Failure Gastrointestinal Diseases
PPARG peroxisome proliferator-activated receptor gamma Ischemic heart disease Stomach Neoplasms
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Heart Failure Stomach Ulcer
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Cardiovascular Diseases; Heart Failure Stomach Ulcer; Stomach Neoplasms
PYCARD PYD and CARD domain containing Heart Valve Diseases Stomach Neoplasms
RELA   Cardiovascular disease, unspecified Gastric cancer
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Heart Failure Stomach Neoplasms
SOD2 superoxide dismutase 2, mitochondrial Heart Failure Stomach Neoplasms
TNF tumor necrosis factor Congestive heart failure Stomach Ulcer; Stomach Neoplasms
VEGFA vascular endothelial growth factor A Heart Diseases; Heart Failure Stomach Ulcer
ACHE Acetylcholinesterase Heart Failure Stomach Tumor
AR Androgen Receptor Atherosclerosis Gastric Cancer
CYP2A6 Cytochrome P450 2A6 Cardiovascular Disease Gastric Carcinoma
ESR1 Estrogen Receptor Ischemia Reperfusion Injury Gastric Cancer
GLO1 Glyoxalase I Diabetic Cardiomyopathy Gastric Cancer
MMP9 Matrix metalloproteinase 9 Heart Failure Gastric Carcinoma
NR3C1 Glucocorticoid receptor Coronary Heart Disease Gastric Cancer
PLA2G2A Phospholipase A2 group IIA Atherosclerosis Gastric Cancer
PLK2 Polo-Like Kinase 2 Myocardial Infarction Stomach Tumor