Table 5.
Comparison of biochemical indexes between typed drug-induced liver injury and primary biliary cirrhosis patients (median)
| TP (g/L) | ALB (g/L) | AST (U/L) | ALT (U/L) | ALP (U/L) | GGT (U/L) | TBIL (μmol/L) | DBIL (μmol/L) | IBIL (μmol/L) | |
| Hepatocellular type DILI (n = 90) | 66.8 ± 8.0a | 39.2 ± 6.2 | 442.5 (174.3-941.5)a | 574.0 (205.6-1263.3)ace | 145.5 (86.3-217.5)ace | 179.0 (87.0-366.1)a | 74.30 (32.4-160.7) | 46.2 (17.8-96.6) | 16.2 (11.4-19.5) |
| Cholestatic type DILI (n = 20) | 63.7 ± 7.2a | 39.1 ± 5.8 | 135.0 (82.6-185.8) | 154.0 (49.2-253.8) | 320.6 (196.6-454.2) | 208.50 (110.5-426.8) | 126.90 (55.3-266.7) | 99.0 (38.8-214.3) | 26.2 (13.3-35.2) |
| Mixed type DILI (n = 14) | 70.8 ± 8.6 | 37.6 ± 4.4 | 654.1 (317.2-1389.1)ac | 844.0 (551.8-1945.8)ac | 328.75 (258.4-477.2) | 260.50 (142.8-418.5) | 111.10 (41.3-234.9)a | 95.2 (56.7-266.8)a | 21.9 (14.6-33.2)a |
| PBC (n = 116) | 74.9 ± 9.4 | 37.6 ± 6.0 | 113.5 (74.8-190.5) | 113.0(69.0-193.3) | 264.0 (166.3-443.3) | 311.5 (148.0-660.3) | 78.6 (25.2-189.0) | 16.3 (5.8-60.6) | 10.9 (7.4-21.6) |
a
P < 0.05 vs the PBC group;
c
P < 0.05 vs the cholestatic type DILI group;
e
P < 0.05 vs the mixed type DILI group. DILI: Drug-induced liver injury; PBC: Primary biliary cirrhosis; TP: Total protein; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; GGT: Gamma glutamyl transferase; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; ALP: Alkaline phosphatase.