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. 2016 Sep 6;6:32658. doi: 10.1038/srep32658

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Copyright © 2016, The Author(s)

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KCTD1 was incubated for 2 hours at 37 °C with or without 20 μM Cu²⁺. (a) Freshly purified KCTD1 presented no aggregates. (b,c) KCTD1 incubated without Cu²⁺ formed aggregates with irregular morphologies. (d,e) KCTD1 incubated with Cu²⁺ formed fibrillar aggregates. Irregular aggregates and fibrillar aggregation in (b–e) were indicated with black arrow mark.