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. 2016 Sep 6;6:32779. doi: 10.1038/srep32779

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Copyright © 2016, The Author(s)

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(A) Chemical structures of Triptonide and (B) troptolide are displayed. (C) Triptonide (TN in the figure) effectively inhibits Wnt/β-catenin signaling induced by Wnt3a conditional media (Wnt3a-CM) in STF293 cells that were stably transfected with TOPFLASH luciferase plasmid. The data was represented as mean relative luciferase activities (RLA) + SEM (n = 3). All the P values are compared to the luciferase activity induced by Wnt3a-CM (*P < 0.05; **P < 0.01). (D) Western blotting showed that triptonide did not attenuate Wnt3a-CM-induced active β-catenin expression.