Table 4. Fold change in expression of miRNAs and their target genes in cancer and precancer.
| miRNA | Cancer (n = 23) | LK (n = 18) | LP (n = 12) | OSMF (n = 23) | Targets | Cancer | LK | LP | OSMF |
|---|---|---|---|---|---|---|---|---|---|
| hsa-miR-204 | 23 ↓* | 4 ↑ | 3 ↑* | 8 ↓* | MMP9 | 19 ↑* | 2 ↓ | 3 ↑ | 1 |
| PLAUR | 5 ↑* | 2 ↓ | 3 ↓ | 2 ↑ | |||||
| SERPINE1 | 25 ↑* | 1 | 1 | 3 ↑ | |||||
| SNAI2 | 3 ↑ | 2 ↓ | 2 ↓ | 1 | |||||
| COL5A3 | 2 ↑ | 2 ↓ | 2 ↓ | 1 | |||||
| hsa-miR-31 | 30 ↑* | 68 ↑* | 19 ↑* | 3 ↑* | DMD | 106 ↓* | 4 ↓ | 10 ↓ # | 5 ↑ |
| CXCL12 | 3 ↓* | 10 ↓* | 17 ↓ # | 1 | |||||
| WASF3 | 2 ↓ | 3 ↓* | 7 ↓ # | 1 | |||||
| hsa-miR-31* | 41 ↑* | 65 ↑* | 182 ↑* | 2 ↑ | KIAA1737 | 2 ↓ | 2 ↓ | 4 ↓ # | 2 ↑ |
| has-miR-7 | 2 ↑* | 6 ↑* | 14 ↑* | 1 | TGM2 | 1 | 3 ↓ | 5 ↓ | 2 ↑ |
| has-miR-133a | 209 ↓* | 20 ↑* | 1 | 3 ↑ | RUNX3 | 2 ↑* | ND | ND | ND |
| H2AFX | 1.5 ↑* | ND | ND | ND | |||||
| MTHFDIL | 3 ↑* | ND | ND | ND | |||||
| has-miR-206 | 126 ↓* | 22 ↑* | 3 ↑ | 2 ↑ | FYB | 3 ↑* | ND | ND | ND |
Expression fold change of miRNA and target genes in cancer and pre-cancer tissues were calculated with respect to the normal oral tissues from healthy individuals.*Significant, after independent t-test with P value <0.05 and Benjamini-Hochberg multiple testing correction, ↑: upregulation; ↓: downregulation of expression; LK-Leukoplakia, LP-Lichen planus, OSMF-oral sub-mucous fibrosis, ND: not determined due to non-availability of RNA samples.