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. 2016 Sep 6;16:68. doi: 10.1186/s12935-016-0343-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Apoptosis executioner caspase re-activation and LDH release in TP53-rescued ESS-1 cells. a Caspase-3 and -7 activation (Caspase-Glo 3/7 Assay) of TP53-WT- or TP53-637C>T-transfected ESS-1 cells that were treated with 3 µM SAHA. Different individual caspase inhibitors (C3i, C8i, C9i, CFi) were additionally applied together with SAHA to TP53-WT reconstituted cells as controls. Untreated, SAHA-, (S; 3 µM) and/or TRAIL-treated (T; 100 nM), and untreated TP53-WT-transfected cells served as further controls. b Measurements of LDH release by the CytoTox-ONE homogeneous membrane integrity assay of the samples analyzed in A for determination of the amount of cell cytotoxicity. Statistically significant differences compared to the SAHA-treated control were indicated in a and b