Table 6.

The association between miR-21-5p of and mortality in IPF patients during 30 months using Univariate Cox Hazard model analyses with adjustment for each of the four parameters

The factor for adjustment	Univariate
	HR (95 % CI)a	P value
Sex	1.16 (1.04–1.27)	0.008
Age	1.12 (1.003–1.24)	0.04
Emphysematous lesion detected by CT	1.19 (1.04–1.46)	0.01
KL-6	1.45 (1.15–1.83)	0.002
% predicted VC	1.16 (1.04–1.29)	0.01

Bold represents p < 0.05

HR hazard ratio, CI confidence interval, KL-6 Krebs von den Lungen-6 VC vital capacity

^aA unit hazard ratio (hazard ratio per one copy/SI in normalized serum EV miR-21-5p) is shown