Table 7.
Characteristics of the two groups into which IPF patients were divided according to the median of the normalized levels of serum EV miR-21-5p
| Normalized miR-21-5p (copies/SI) | P value | ||
|---|---|---|---|
| <2.1 | ≥2.1 | ||
| (n = 20) | (n = 21) | ||
| Age, yr | 71 (65–77) | 75 (71–81) | 0.15 |
| Sex, male, n (%) | 19 (95) | 13 (61) | 0.02 |
| Smoking history | |||
| Yes, n (%) | 18 (90) | 16 (76) | 0.4 |
| Baseline VC (%) | 78 (69–104) | 81 (62–91) | 0.48 |
| Emphysematous lesion detected by CT, n (%) | 2 (10) | 2 (10) | 0.96 |
| KL-6 | 645 (540–982) | 1040 (706–1921) | 0.04 |
| SP-D | 211 (141–277) | 202 (140–320) | 0.77 |
| LDH | 207 (183–215) | 227 (177–280) | 0.18 |
The data are expressed as n (%) or median (IQR). The differences in age, % VC, or other serum markers between the two groups were analysed by the Mann-Whitney U test. The comparison of gender, smoking history and emphysema between the two groups was analysed using the Fisher exact test
Bold represents p < 0.05
VC vital capacity, KL-6 Krebs von den Lungen-6, SP-D surfactant protein D