Table 11.
Induced ESR gene set: comparison between NEAT and LA+S (KEGG pathways)
| μ 0 | log10 (p-value) | ||||
|---|---|---|---|---|---|
| KEGG pathway | NEAT | LA+S | NEAT | LA+S | |
| 1 | Starch and sucrose metabolism | 394.2 | 400.6 | <-300 | <-300 |
| 2 | Butanoate metabolism | 84.8 | 98.0 | –202.8 | <-300 |
| 3 | Pentose and glucuronate interconversions | 110.7 | 127.5 | –119.9 | –185.7 |
| 4 | beta-Alanine metabolism | 104.0 | 122.9 | –118.0 | –209.8 |
| 5 | Glycolysis/Gluconeogenesis | 616.3 | 618.7 | –116.5 | –149.3 |
| 6 | Fructose and mannose metabolism | 200.0 | 206.2 | –106.7 | –160.7 |
| 7 | Galactose metabolism | 173.9 | 193.2 | –104.5 | –126.4 |
| 8 | Glycerolipid metabolism | 172.1 | 193.2 | –72.7 | –103.2 |
| 9 | Longevity regulating pathway - multiple species | 544.0 | 508.2 | –70.6 | –79.1 |
| 10 | Pentose phosphate pathway | 288.0 | 284.2 | –64.0 | –105.8 |
| 11 | Amino sugar and nucleotide sugar metabolism | 264.2 | 277.6 | –63.4 | –66.7 |
| 12 | Peroxisome | 313.3 | 332.9 | –61.2 | –55.8 |
| 13 | Glutathione metabolism | 204.8 | 221.6 | –59.9 | –77.8 |
| 14 | Taurine and hypotaurine metabolism | 24.3 | 28.5 | –59.4 | –92.8 |
| 15 | Tyrosine metabolism | 163.5 | 169.9 | –51.8 | –62.6 |
| 16 | Tryptophan metabolism | 113.3 | 130.9 | –48.2 | –59.4 |
| 17 | Valine, leucine and isoleucine degradation | 107.5 | 124.8 | –45.3 | –56.8 |
| 18 | Other glycan degradation | 11.7 | 12.9 | –44.2 | –66.3 |
| 19 | Regulation of autophagy | 126.7 | 135.2 | –43.3 | –45.5 |
| 20 | Pyruvate metabolism | 355.9 | 388.8 | –42.8 | –41.6 |
| 21 | Alanine, aspartate and glutamate metabolism | 262.2 | 284.5 | –38.0 | –36.7 |
| 22 | Fatty acid degradation | 215.0 | 225.0 | –37.2 | –43.7 |
| 23 | Citrate cycle (TCA cycle) | 267.3 | 299.5 | –35.6 | –32.9 |
| 24 | Insulin resistance | 172.8 | 176.5 | –30.1 | –30.4 |
| 25 | Histidine metabolism | 127.4 | 147.8 | –28.8 | –25.8 |
| 26 | Arachidonic acid metabolism | 36.7 | 44.1 | –28.1 | –40.6 |
| 27 | Glyoxylate and dicarboxylate metabolism | 201.6 | 224.8 | –27.3 | –23.7 |
| 28 | Sphingolipid metabolism | 103.6 | 116.3 | –27.3 | –26.2 |
| 29 | Arginine and proline metabolism | 154.3 | 180.2 | –27.0 | –24.8 |
| 30 | Lysine degradation | 150.4 | 160.2 | –26.6 | –31.5 |
| 31 | Methane metabolism | 254.2 | 262.7 | –26.2 | –23.7 |
| 32 | Phenylalanine metabolism | 71.4 | 81.5 | –25.0 | –26.4 |
| 33 | Glycerophospholipid metabolism | 270.9 | 285.1 | –24.5 | –22.3 |
| 34 | Protein processing in endoplasmic reticulum | 866.0 | 857.1 | –17.4 | –20.7 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis | 41.8 | 47.1 | –13.1 | –12.3 |
| 36 | Propanoate metabolism | 107.3 | 122.9 | –12.9 | –9.9 |
| 37 | alpha-Linolenic acid metabolism | 27.1 | 30.5 | –11.7 | –11.2 |
| 38 | Fatty acid elongation | 75.3 | 76.1 | –10.8 | –12.9 |
| 39 | Glycine, serine and threonine metabolism | 264.3 | 281.1 | –6.7 | –3.5 |
| 40 | Nicotinate and nicotinamide metabolism | 99.8 | 111.9 | –6.7 | –4.7 |
| 41 | Nitrogen metabolism | 52.8 | 60.7 | –5.4 | –4.0 |
| 42 | Thiamine metabolism | 32.9 | 36.8 | –4.1 | –3.2 |
| 43 | Selenocompound metabolism | 89.3 | 97.0 | –3.2 | –1.9 |
| 44 | Cysteine and methionine metabolism | 285.3 | 310.6 | –2.8 | –1.0 |
| 45 | Arginine biosynthesis | 134.0 | 154.2 | –2.4 | –0.6 |
| 46 | Sulfur metabolism | 105.3 | 121.9 | –2.2 | –0.5 |
| 47 | Biosynthesis of unsaturated fatty acids | 103.9 | 102.1 | –2.5 | –3.1 |
| 48 | Regulation of mitophagy - yeast | 554.4 | 510.4 | –1.6 | –5.1 |
The table reports the gene sets that are found to be over-enriched (α=1 %) by at least one of the two methods. μ 0 denotes the expected value of N AB in absence of enrichment. The last two columns report log 10 p-values for the proposed NEAT and the LA+S test of [19], respectively