Table 6.

Network enrichment analysis of the repressed ESR gene set

	Gene set	n AB	μ 0	log 10 (p-value)
	Go Slim BP sets:
1	Cytoplasmic translation	6878	2641.9	<-300
2	Ribosomal large subunit biogenesis	3408	1097.8	<-300
3	Ribosomal small subunit biogenesis	5861	2073.7	<-300
4	Ribosome assembly	1782	621.9	<-300
5	RNA modification	2944	1062.0	<-300
6	rRNA processing	9187	3290.2	<-300
7	tRNA processing	2037	901.0	<-300
8	Translational elongation	1786	782.3	–283.8
9	Ribosomal subunit export from nucleus	1420	561.4	–281.8
10	Translational initiation	939	462.5	–112.1
11	Transcription from RNA polymerase III promoter	565	228.4	–107.7
12	SnoRNA processing	634	303.3	–82.0
13	Regulation of translation	1952	1328.6	–73.5
14	DNA-dependent transcription, termination	774	447.0	–57.5
15	Transcription from RNA polymerase I promoter	1005	646.4	–49.5
16	Protein alkylation	1063	759.4	–31.4
17	tRNA aminoacylation for protein translation	400	233.1	–29.4
18	Peptidyl-amino acid modification	1088	883.0	–13.2
19	Nuclear transport	3154	2003.5	–162.4
20	Organelle assembly	2090	1362.7	–96.1
21	Nucleobase-containing compound transport	1453	1155.4	–20.8
22	Cytokinesis	1024	806.9	–16.0
23	Vitamin metabolic process	325	274.0	–3.1
	KEGG pathways:
24	Ribosome biogenesis in eukaryotes	9824	3661.0	<-300
25	Ribosome	18640	8731.7	<-300
26	RNA polymerase	3057	1541.2	<-300
27	RNA transport	4341	2906.4	–177.6
28	Aminoacyl-tRNA biosynthesis	1433	960.9	–58.2
29	RNA degradation	2560	1939.3	–51.9
30	mRNA surveillance pathway	1768	1413.5	–24.0
31	Pentose phosphate pathway	1126	947.1	–9.7
32	Spliceosome	2649	2523.6	–2.3
33	Purine metabolism	5579	3623.0	–263.6
34	Pyrimidine metabolism	4541	2884.5	–234.9
35	Cyanoamino acid metabolism	218	158.8	–6.3
36	One carbon pool by folate	541	392.5	–15.0
37	Sulfur relay system	238	196.5	–2.9
38	Carbapenem biosynthesis	117	89.8	–2.7

The table lists the 23 Go Slim BP gene sets and the 15 KEGG pathways which the set of repressed ESR genes is found to be over-enriched with at 1 % significance level