Table 8.
Network enrichment analysis of the induced ESR gene set (KEGG pathways)
| KEGG pathway | n AB | μ 0 | log 10 (p-value) | |
|---|---|---|---|---|
| 1 | Starch and sucrose metabolism | 1436 | 394.2 | <-300 |
| 2 | Pentose and glucuronate interconversions | 414 | 110.7 | –119.9 |
| 3 | Glycolysis/Gluconeogenesis | 1235 | 616.3 | –116.5 |
| 4 | Fructose and mannose metabolism | 562 | 200.0 | –106.7 |
| 5 | Galactose metabolism | 511 | 173.9 | –104.5 |
| 6 | Amino sugar and nucleotide sugar metabolism | 567 | 264.2 | –63.4 |
| 7 | Other glycan degradation | 79 | 11.7 | –44.2 |
| 8 | Pyruvate metabolism | 633 | 355.9 | –42.8 |
| 9 | Propanoate metabolism | 189 | 107.3 | –12.9 |
| 10 | Glycerolipid metabolism | 444 | 172.1 | –72.7 |
| 11 | Peroxisome | 633 | 313.3 | –61.2 |
| 12 | Fatty acid degradation | 419 | 215.0 | –37.2 |
| 13 | Arachidonic acid metabolism | 117 | 36.7 | –28.1 |
| 14 | Sphingolipid metabolism | 227 | 103.6 | –27.3 |
| 15 | Glycerophospholipid metabolism | 450 | 270.9 | –24.5 |
| 16 | alpha-Linolenic acid metabolism | 69 | 27.1 | –11.7 |
| 17 | Fatty acid elongation | 138 | 75.3 | –10.8 |
| 18 | Biosynthesis of unsaturated fatty acids | 134 | 103.9 | –2.5 |
| 19 | Glutathione metabolism | 467 | 204.8 | –59.9 |
| 20 | Citrate cycle (TCA cycle) | 487 | 267.3 | –35.6 |
| 21 | Ubiquinone and other terpenoid-quinone biosynthesis | 96 | 41.8 | –13.1 |
| 22 | Protein processing in endoplasmic reticulum | 1121 | 866.0 | –17.4 |
| 23 | Longevity regulating pathway | 987 | 544.0 | –70.6 |
| 24 | beta-Alanine metabolism | 397 | 104.0 | –118.0 |
| 25 | Taurine and hypotaurine metabolism | 132 | 24.3 | –59.4 |
| 26 | Tyrosine metabolism | 382 | 163.5 | –51.8 |
| 27 | Tryptophan metabolism | 292 | 113.3 | –48.2 |
| 28 | Valine, leucine and isoleucine degradation | 276 | 107.5 | –45.3 |
| 29 | Alanine, aspartate and glutamate metabolism | 488 | 262.2 | –38.0 |
| 30 | Histidine metabolism | 267 | 127.4 | –28.8 |
| 31 | Arginine and proline metabolism | 301 | 154.3 | –27.0 |
| 32 | Lysine degradation | 294 | 150.4 | –26.6 |
| 33 | Phenylalanine metabolism | 171 | 71.4 | –25.0 |
| 34 | Glycine, serine and threonine metabolism | 350 | 264.3 | –6.7 |
| 35 | Cysteine and methionine metabolism | 338 | 285.3 | –2.8 |
| 36 | Arginine biosynthesis | 167 | 134.0 | –2.4 |
| 37 | Butanoate metabolism | 460 | 84.8 | –202.8 |
| 38 | Pentose phosphate pathway | 604 | 288.0 | –64.0 |
| 39 | Regulation of autophagy | 303 | 126.7 | –43.3 |
| 40 | Insulin resistance | 337 | 172.8 | –30.1 |
| 41 | Glyoxylate and dicarboxylate metabolism | 368 | 201.6 | –27.3 |
| 42 | Methane metabolism | 435 | 254.2 | –26.2 |
| 43 | Nicotinate and nicotinamide metabolism | 154 | 99.8 | –6.7 |
| 44 | Nitrogen metabolism | 88 | 52.8 | –5.4 |
| 45 | Thiamine metabolism | 57 | 32.9 | –4.1 |
| 46 | Selenocompound metabolism | 122 | 89.3 | –3.2 |
| 47 | Sulfur metabolism | 133 | 105.3 | –2.2 |
The table lists the 47 KEGG pathways which the set of induced ESR genes is found to be over-enriched with at 1 % significance level