Fig. 2.

Disease characteristics of the transgenic and transplant Vk*MYC models. a Bar graph depicting grade of disease in the Vk*MYC mouse models. b BMMC lymphocyte analysis in Vk*MYC mouse models: Box and whisker plots showing B lymphocyte (top) and T lymphocyte (bottom) populations. B cells are identified as B220⁺CD19⁺ events and T cells are identified as TCRβ⁺B220⁻ events, and are expressed as % viable cells from the FS/SS lymphocyte gate. (Left) Transgenic Vk*MYC (middle) Transplant Vk#4929 (right) Transplant Vk#31. Closed circles represent age-matched wild type control (a-m WT), open circles represent diseased mice [which are subdivided into low, intermediate (int.) or high-grade disease as described in a]. c Splenic lymphocyte analysis in Vk*MYC mouse models: Box and whisker plots (as described for b)