Table 4.
Predictive factors for DFS according to univariate and multivariate analyses
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | 95 % CI | P-value | HR | 95 % CI | P-value | |
| Age (years) | ||||||
| >60 / ≤ 60 | 1.79 | 1.06-3.02 | 0.028 | 1.86 | 1.04-3.31 | 0.036 |
| Sex | ||||||
| Male / Female | 1.11 | 0.66-1.84 | 0.702 | |||
| BMI (kg/m2) | ||||||
| >23 / ≤ 23 | 1.05 | 0.64-1.75 | 0.839 | |||
| PreOP CEA (ng/ml) | ||||||
| >5 / ≤ 5 | 2.28 | 1.34-3.86 | 0.002 | 1.87 | 1.06-3.30 | 0.032 |
| Previous abdominal operation | ||||||
| + / - | 1.05 | 0.59-1.89 | 0.863 | |||
| Combined resection of an adjacent organ | ||||||
| + / - | 1.40 | 0.82-2.38 | 0.217 | |||
| Tumor location | ||||||
| Rectum / Colon | 2.92 | 1.76-4.87 | <0.001 | 3.25 | 1.85-5.74 | <0.001 |
| Clinical Obstruction | ||||||
| + / - | 1.14 | 0.67-1.91 | 0.634 | |||
| Clinical Perforation | ||||||
| + / - | 1.73 | 0.82-3.63 | 0.152 | |||
| Operative technique | ||||||
| Laparoscopic / Open | 0.77 | 0.40-1.49 | 0.435 | |||
| Pathologic T stage | ||||||
| T4 / T2 + T3 | 1.77 | 1.07-2.95 | 0.027 | 2.22 | 1.26-3.93 | 0.006 |
| Pathologic N stage | ||||||
| + / - | 2.20 | 1.29-3.77 | 0.004 | 1.22 | 0.63-2.36 | 0.556 |
| Differentiation of cell | ||||||
| PD + MUC + Signet / WD + MD | 1.35 | 0.73-2.50 | 0.333 | |||
| Lymphatic invasion | ||||||
| + / - | 1.37 | 0.80-2.33 | 0.253 | |||
| Vascular invasion | ||||||
| + / - | 2.08 | 1.15-3.75 | 0.015 | 1.60 | 0.79-3.26 | 0.194 |
| Perineural invasion | ||||||
| + / - | 1.79 | 0.90-3.56 | 0.097 | 0.81 | 0.38-1.76 | 0.600 |
| Adjuvant chemotherapy | ||||||
| + / - | 0.65 | 0.35-1.20 | 0.169 | |||
PreOP CEA Preoperative carcinoembryonic antigen, WD Well differentiated, MD Moderately differentiated, PD Poorly differentiated, MUC Mucinous adenocarcinoma, signet Signet ring cell type