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The consecutive dose of midazolam according to the up-down method for patients in their 30s. The number of patients required to get the 15th crossover point (•→○ or ○→•) was 28. If memories of injection pain remained (•), the dosage was increased by 0.01 mg/kg for the next patient, and then if memories were erased (○), the dosage was decreased by 0.01 mg/kg.
