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. 2014 Jul 28;2(3):121–124. doi: 10.4103/2321-3868.135483

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© Author 2014

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

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Figure 2: — Role of bone marrow tyrosine kinase on chromosome X (BMX) in Toll-like receptor (TLR)4 signaling. BMX has been reported to interact with adaptor molecules (MyD88, or Mal) and transforming growth factor (TGF)-β activated kinase (TAK)1, leading to the activation of the NF-κB and MAPK-signaling pathways. This process results in inflammatory cytokine production. MD = myeloid differentiation protein, TRIF = Toll/interleukin-1 receptor domain-containing adaptor protein inducing interferon-β, TRAM = TRIF-related adaptor molecule, IRAK = interleukin-1 receptor-associated kinase, TRAF = TNF receptor-associated factor, MAPK = mitogen-activated protein kinases, IKK = inhibitor kappa B kinase, AP = activator protein.