Fig. 5.

p190-B promotes cell movement and inhibits RhoA activation. SMMC-7721 cells were transfected with a pool of siRNAs targeting p190-B or siCtrl. a Quantitative analysis of relative migration distance by wound-healing assay. ***p < 0.001 by student’s t test. b Quantification of RhoA activation in indicated cells at 48 h after transfection. *p < 0.05 by student’s t test. c Cells were stained with DAPI, rhodamine-conjugated phalloidin and an antibody against paxillin and imaged by confocal microscopy. Arrows indicate focal adhesions. Error bars indicate SD from at least triplicate determinations