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. 2016 Sep 6;16(1):719. doi: 10.1186/s12885-016-2755-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Overview of novel lncRNA candidates associated with NPC radioresistance. a The length distributions of the transcripts. b The novel transcripts identified in CNE-2 and CNE-2-Rs cells. The shaded areas represented the lncRNAs found in both samples, and the areas coloured red and blue showed the number of lncRNAs expressed in samples CNE-2 and CNE-2-Rs, respectively. c Scatter plot of lncRNA expression profiles in radiosensitive CNE-2 (x-axis) and radioresistant CNE-2-Rs cells (y-axis). The significantly up-regulated novel lncRNAs were marked in red and the down-regulated lncRNAs in blue. |log2 Fold change| ≥ 1 and FDR < 0.001. d Validation of the expression of the top five up-regulated and down-regulated novel transcripts via qRT-PCR