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. 2016 Sep 6;9(1):194. doi: 10.1186/s13068-016-0607-x

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Comparison of experimental and simulated metabolic fluxes for optimal growth of C. thermocellum on cellobiose without tuned growth-associated maintenance (GAM) ATP requirement. FBA simulation used only experimentally determined cellobiose uptake as a constraint. b Identification of best-fit GAM ATP requirement. The model energy balance was tuned by altering GAM ATP requirement and optimizing growth rate with specified fermentation constraints. Dotted lines frame the experimentally observed growth rate range, while solid lines illustrate the average observed growth rate and the best-fit GAM ATP requirement. c Comparison of experimental and simulated metabolic fluxes for optimal growth of C. thermocellum on cellobiose with tuned GAM ATP requirement