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. 2016 Sep 6;8(1):92. doi: 10.1186/s13148-016-0256-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a A schematic representation of the NR3C1 5′ UTR structure, showing the alternative first exons (1A–1J, CpG island: ), transcription factor binding sites (1–25), transcriptional loci (B1–B5), and microvariable transcription start sites (•). Transcription factor binding sites: () IRF-1 and IRF-2 (position 1); () glucocorticoid response elements (GRE, positions 2, 3, 8, 11, 14, and 22); () c-Myb, c-Ets1/2 and PU1 (position 4); () Ying Y and 1 (positions 5, 6, 7, and 25); (■) Sp1 binding sites (positions 9, 10, 12, 13, 16, 19, 20, 21, and 24); () Ap-1 (position 15); () NGFI-A binding site (position 17); () glucocorticoid response factor-1 (GRF-1, position 18); (□) Ap-2 (position 23). b Structure of the GR mRNA with the internal ATG translation initation codons, a western blot demonstrating the different transcriptional isoforms (from [113] with permission), and the frequency of the different protein isoforms with increasing 5′ UTR length (adapted from [111] with permission)

Inline graphic — a A schematic representation of the NR3C1 5′ UTR structure, showing the alternative first exons (1A–1J, CpG island: ), transcription factor binding sites (1–25), transcriptional loci (B1–B5), and microvariable transcription start sites (•). Transcription factor binding sites: () IRF-1 and IRF-2 (position 1); () glucocorticoid response elements (GRE, positions 2, 3, 8, 11, 14, and 22); () c-Myb, c-Ets1/2 and PU1 (position 4); () Ying Y and 1 (positions 5, 6, 7, and 25); (■) Sp1 binding sites (positions 9, 10, 12, 13, 16, 19, 20, 21, and 24); () Ap-1 (position 15); () NGFI-A binding site (position 17); () glucocorticoid response factor-1 (GRF-1, position 18); (□) Ap-2 (position 23). b Structure of the GR mRNA with the internal ATG translation initation codons, a western blot demonstrating the different transcriptional isoforms (from [113] with permission), and the frequency of the different protein isoforms with increasing 5′ UTR length (adapted from [111] with permission)